Extract and run OperaPortable.
Edit OperaPortable.ini to choose Open & Save Dir, not empty cache, not backup icons & thumbnails...
Settings of installed Opera should be preserved.

Startup Manager updated to v1.6
Registry Cleaner updated to v3.5
IE Manager updated to v2.1
Add some tweaks

Fixed files not transferring during upload in a scheduled transfer, this was a compatibility issue with older versions of windows. Windows 7 users were not effected.
Fixed toolbar rendering on older versions of windows or when themes were disabled.
Fixed issue with the per-site connection retry count of 0 when using the task scheduler or command line file transfers FlashFXP would never automatically close.

This is a maintenance release. The following items were fixed and/or added:
Mac OS X hosts: fixed incompatibility with recent Mac OS X versions in 64-bit mode (bug #8474)
Mac OS X hosts: fixed incompatibility with hosts with more than 16 cores (bug #8389)
Mac OS X hosts: fixed painting corruptions on a second monitor in 64-bit mode (bug #7606)
GUI: restored functionality to set an empty host key to disallow any host key combination (4.0.6 regression; bug #8793)
VBoxManage: added controlvm screenshotpng subcommand for saving the screenshot of a running VM in PNG format
VBoxHeadless: fixed potential crash during shutdown (Windows hosts only)
NAT: built-in services use the correct Ethernet addresses in Ethernet header and in ARP requests
Host-only networking: fixed adapter reference counting
E1000: fixed rare guest crashes with Linux SMP guests (bug #8755)
SATA: fixed guest disk corruption under rare circumstances (only relevant for guests with more than 2GB RAM; bug #8826)
Storage: fixed data corruption after a snapshot was taken with asynchronous I/O enabled (bug #8498)
Floppy: several improvement
HPET: another fix for time jumps (bug #8707)
USB: removed assumption that string descriptors are null-terminated (Windows hosts only)
3D support: fixed a potential crash when resizing the guest window
3D support: fixed GNOME 3 rendering under Ubuntu 11.04 and Fedora 15
Snapshots: fixed another bug which could lose entries in the media registry when restoring a snapshot (bug #8363)
Shared Folders: don't stop mounting the other valid folders if one host folder is inaccessible (4.0.6 regression)
Linux Additions: check whether gcc and make are installed before building kernel modules (bug #8795)
Solaris Additions: added support for X.Org Server 1.10
Guest Additions: fixed inappropriate Guest Additions update notification when using vendor-specific version suffixes (bug #8844)

Fixed another blocking issue when processing multiple parallel tasks
Using AviSynth to decode MKV/M2TS/TS as first priority (and fallback to MEncoder)
Added an option to toggle video decoder fallback (overall.video.fallback)
Fixed AviSynth audio decoding problem on some systems
Restored missing dual audio support in recent builds
Fixed per-task preset file not loading bug
Fixed serveral long existing minor bugs